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Provista Blog > What Are The Effects of Having Extremely Dense Breasts?

Provista Blog

What Are The Effects of Having Extremely Dense Breasts?

Posted by Provista Diagnostics on March 8, 2017

Breast density can considerably influence the precision of routine methods of detection, such as screening mammography. All imaging modalities rely on visual interpretations of a woman's breasts, and for patients with dense breasts that visual interpretation can be confounded by increased glandular tissue, obscuring cancers. In particular, women with extremely breast dense, which makes up about 10 percent of women, have a higher likelihood of developing cancer and receiving a later diagnosis. This occurs because deciding between healthy and dense breast tissue and cancer is extremely difficult, as both appear white on imaging, this is often likened to trying to spot a polar bear in a snowstorm. 


50 percent of women have dense breasts.


What is dense breast tissue?

Dense breasts have less fatty tissue and more non-fatty tissue. Breast density can be inherited, therefore, if your mother has dense breasts, there is an increased likelihood you will also have dense breasts.

BI-RADS classifies breast density into four groups:

  1. Mostly fatty: The breasts are made up of mostly fat and contain little fibrous and glandular tissue. This means the mammogram would likely show anything that was abnormal.

  2. Scattered density: The breasts have quite a bit of fat, but there are a few areas of fibrous and glandular tissue.

  3. Heterogeneously dense (consistent density): The breasts have many areas of fibrous and glandular tissue that are evenly distributed through the breasts. This can make it hard to see small masses in the breast.

  4. Extremely dense breasts: The breasts have a lot of fibrous and glandular tissue. This may make it hard to see a cancer on a mammogram because the cancer can blend in with the normal tissue. 

What causes dense breasts?

It is not exactly clear why some women have dense breast tissue and others do not.

Though it may be more likely to have dense breasts for:

  • Women in their 40s and 50s are most likely to have dense breast tissue. Breast tissue tends to become less dense as with age.
  • Pre-menopausal women are more likely to have dense breasts.
  • Women who take combination hormone therapy to relieve signs and symptoms of menopause are more likely to have dense breasts.

What tests are recommended for breast cancer screening?

Mammograms are recommended as a first-line breast cancer screening in women with dense breast tissue. Women with dense breasts, but no other risk factors for breast cancer, are considered to have an average risk. Despite this, mammography relies on a visual interpretation of imaging results that are often confounded by dense breast tissue, this is particularly problematic for the 10 percent of women with extremely dense breasts. Women with Category D, or extremely dense breasts have more glandular tissue (which appears white on mammograms, similar to cancer) than fibrous tissue. In over half the country, legislation has been enacted to ensure women are aware of their density status. However, supplemental tests are not required or necessarily covered across the country.  

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There are clear advantages and disadvantages to each set of diagnostic imaging test. However, there is no simple, cost effective solution for women with dense breasts to obtain a definitive detection status through imaging. For women with an abnormal or unclear imaging finding, utilizing a complementary blood-based approach in addition to current standard-of-care could aid in early detection or help rule-out breast cancer irrespective of breast density. A blood-based approach would allow for detection to be based on physiology, rather than anatomy, while being cost effective to patients. This would also reduce stress and uncertainty to patients with both heterogeneously dense and extremely dense breasts and their families. 

Provista Diagnostics

Provista Diagnostics

At Provista Diagnostics, our mission is to develop world-class diagnostic tests for indications in breast and gynecologic cancers. As a leading diagnostics company, our aim is to create, produce and market innovative solutions for unmet clinical needs. Our products and services help to diagnose diseases and inform better clinical decisions, thus enhancing women’s health and quality of life. We do this in a responsible and ethical manner with a commitment to excellence in every aspect of our business.