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Provista Blog > What Are Protein Biomarkers Doing For Breast Cancer?

Provista Blog

What Are Protein Biomarkers Doing For Breast Cancer?

Posted by Provista Diagnostics on December 27, 2016



Despite advances in imaging technologies, the ability to accurately detect breast cancer remains challenging. This leads to situation where patients might be under or over treated, which can result in extra costs and anxiety to patients, health care providers and the health care system as a whole. As a result, we need a diagnostic tool to complement imaging when results are hard to interpret.

Innovations in science and cancer research have allowed us to detect cancer at the cellular level by identifying biomarkers in the blood. Proteomic technologies can identify changes in protein signatures in the blood specific to breast cancer. It detects the absence of disease related biomarkers in real time. 



Some breast cancers are more aggressive than others and biomarkers can help determine when cancer is likely to grow rapidly and/or metastasize, thus influencing treatment decisions. To improve patient outcomes and detect breast cancer as early as possible we must use ProteoMark technology, which allows us to gain reliable protein signatures in the blood. This technology analyses two types of biomarkers; Serum Protein Biomarkers (SPBs) and Tumor-Associated Autoantibodies (TAAbs) and allows us to rule out breast cancer in patients independent of anatomy, family history and biopsy.


TAAbs are the body's immune response that are released into the bloodstream when the presence of tumor proteins are detected. TAAbs are stable, highly specific and easily detected in serum. 

SPBs are produced either by the host, surrounding environment or tumor including proteins involved in, but not limited to, inflamation, angiogenesis and cell growth.  In the presence of cancer, these processes can aid in tumor development and/or progression.

It has been conclusively demonstrated that by including both SPBs and TAAb’s with the same signature, we are able to capture cancer signals from eight of the ten "Hallmarks of Cancer." This comprehensive approach is the key to early and accurate breast cancer detection.

Provista Diagnostics

Provista Diagnostics

At Provista Diagnostics, our mission is to develop world-class diagnostic tests for indications in breast and gynecologic cancers. As a leading diagnostics company, our aim is to create, produce and market innovative solutions for unmet clinical needs. Our products and services help to diagnose diseases and inform better clinical decisions, thus enhancing women’s health and quality of life. We do this in a responsible and ethical manner with a commitment to excellence in every aspect of our business.