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Provista Blog > The "Hallmarks of Cancer" & Breast Cancer Detection

Provista Blog

The "Hallmarks of Cancer" & Breast Cancer Detection

Posted by Provista Diagnostics on December 1, 2016

In 2000 and 2011, Douglas Hanahan & Robert A Weinberg published two seminal articles titled “Hallmarks of Cancer," published in Cell. These articles hypothesized that all tumor cells need to possess 10 capabilities in order to transform into invasive cancer cells.

10 Hallmarks of CancerHallmarks-of-cancer

  1. Evading Growth Suppressors

  2. Avoiding Immune Destruction

  3. Deregulating Cellular Energetics

  4. Tumor-Promoting Inflammation

  5. Genome Instability & Mutation

  6. Inducing Angiogenesis

  7. Activating Invastion & Metastasis

  8. Resisting Cell Death

  9. Enabling Replicative Immortality

  10. Sustaining Proliferative Signaling



So, what does this have to do with advancing breast cancer detection?

  • Each of these “hallmarks of cancer” involves cellular pathways mitigated by numerous proteins.
  • By identifying proteins involved with each of the hallmarks, we can isolate and measure these proteins and determine their relationship with breast cancer development.

  • Proteins constantly change as a consequence of disease and therefore provide insight into biological processes associated with cancer development

  • Proteomic tests detect the present of absence of disease related biomarkers in real time, based on the physiological state of the patient

  • An inherent advantage proteomics is that a protein itself is the biological endpoint that is responsible for cellular function

The Power of Proteins in Breast Cancer Detection

A diagnostic tool that utilizes proteomic technology to monitored these “Hallmarks of Cancer” could identify changes in patterns or combinations of protein signatures in the blood, specific to a breast cancer. Thus, a tool of this nature, if used in conjunction with imaging, would be able to diagnose patients with breast cancer earlier and more accurately.

Want to read a full guide to relating the hallmarks of cancer relate to breast cancer detection and utilizing protein biomarkers in a liquid biopsy? Download it here


Provista Diagnostics

Provista Diagnostics

At Provista Diagnostics, our mission is to develop world-class diagnostic tests for indications in breast and gynecologic cancers. As a leading diagnostics company, our aim is to create, produce and market innovative solutions for unmet clinical needs. Our products and services help to diagnose diseases and inform better clinical decisions, thus enhancing women’s health and quality of life. We do this in a responsible and ethical manner with a commitment to excellence in every aspect of our business.