Provista Blog > How Do the “Hallmarks of Cancer” Impact Breast Cancer?
Proteins play many critical roles in the body, including acting as precursors for metabolic reactions, DNA replication and intracellular and extracellular communication. The proteom is the entire set of proteins produced or modified by an organizm or system. As a cell transforms from "non-diseased" (benign breast lesions) to "diseased" (invasive breast cancer), distinct changes occur that could act as early warning signals of breast cancer and be potentially detected through biomarkers.
Benign tumors are well-contained and rarely life-threatening, while invasive/metastatic tumors are capable of forming new tumors outside the primary site and are frequently life-threatening. Before invasive cancers can sustain their own growth and invade other parts of the body, multiple cellular pathways must be disrupted.
In 2000 and 2011, Douglas Hanahan & Robert A Weinberg published two seminal articles titled “Hallmarks of Cancer," published in Cell. These articles hypothesized that all tumor cells need to possess 10 capabilities in order to transform into invasive cancer cells.
Evading Growth Suppressors
Avoiding Immune Destruction
Deregulating Cellular Energetics
Genome Instability & Mutation
Activating Invastion & Metastasis
Resisting Cell Death
Enabling Replicative Immortality
Sustaining Proliferative Signaling
A diagnostic tool that utilizes proteomic technology to monitored these “Hallmarks of Cancer” could identify changes in patterns or combinations of protein signatures in the blood, specific to a breast cancer. Thus, a tool of this nature, if used in conjunction with imaging, would be able to diagnose patients with breast cancer earlier and more accurately.
Want to read a full guide to relating the hallmarks of cancer relate to breast cancer detection and utilizing protein biomarkers in a liquid biopsy? Download it here.
At Provista Diagnostics, our mission is to develop world-class diagnostic tests for indications in breast and gynecologic cancers. As a leading diagnostics company, our aim is to create, produce and market innovative solutions for unmet clinical needs. Our products and services help to diagnose diseases and inform better clinical decisions, thus enhancing women’s health and quality of life. We do this in a responsible and ethical manner with a commitment to excellence in every aspect of our business.